Fluvastatin suppresses native and recombinant human P2X4 receptor function
نویسندگان
چکیده
منابع مشابه
Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue.
We isolated a cDNA from human brain encoding a purinergic receptor that shows a high degree of homology to the rat P2X4 receptor (87% identity). By fluorescence in situ hybridization, the human P2X4 gene has been mapped to region q24.32 of chromosome 12. Tissue distribution analysis of human P2X4 transcripts demonstrates a broad expression pattern in that the mRNA was detected not only in brain...
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The P2X4 receptor is involved in endothelium-dependent changes in large arterial tone in response to shear stress and is, therefore, potentially relevant to arterial compliance and pulse pressure. Four identified nonsynonymous polymorphisms in P2RX4 were reproduced in recombinantly expressed human P2X4. Electrophysiological studies showed that one of these, the Tyr315>Cys mutation (rs28360472),...
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ژورنال
عنوان ژورنال: Purinergic Signalling
سال: 2012
ISSN: 1573-9538,1573-9546
DOI: 10.1007/s11302-011-9289-9